| Chemical Properties | Back Directory | [Boiling point ]
565.6±45.0 °C(Predicted) | [density ]
1.098±0.06 g/cm3(Predicted) | [storage temp. ]
Store at Room Tem. | [solubility ]
Soluble in Water, DMSO, DMF, DCM | [pka]
14.36±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Amino-PEG11-alcohol is a crosslinking reagent consisting of an amino (NH2) group with a hydroxyl(OH) group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydroxyl (OH) enables further derivatization. | [Uses]
Amino-PEG11-OH is non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG11-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
Non-cleavable Linker; PEGs | [References]
[1] Synthesis of reduced sensitive azo connection unit and application of azo connection unit in DNA (deoxyribonucleic acid) sequencing. CN103539697A. |
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