| Identification | Back Directory | [Name]
CP 376395 hydrochloride | [CAS]
1013933-37-3 | [Synonyms]
CP-376395 HCl
UNII-5113G7FP34
CP 376395 hydrochloride
(CP376395
CP-376395 hydrochloride >=98% (HPLC) | [Molecular Formula]
C21H30N2O.HCl | [MDL Number]
MFCD11519966 | [MOL File]
1013933-37-3.mol | [Molecular Weight]
362.94 |
| Chemical Properties | Back Directory | [storage temp. ]
Desiccate at RT | [solubility ]
Soluble to 50 mM in water and to 100 mM in DMSO | [form ]
Powder | [color ]
white to beige | [InChI]
1S/C21H30N2O.ClH/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5;/h10-12,18H,8-9H2,1-7H3,(H,22,23);1H | [InChIKey]
UDIOZDHQQNYISB-UHFFFAOYSA-N | [SMILES]
CC1=C(NC(CC)CC)C=C(C)N=C1OC2=C(C)C=C(C)C=C2C.[H]Cl |
| Hazard Information | Back Directory | [Description]
Potent and selective CRF1receptor antagonist (Kivalues are 12 and >10000 nM for CRF1and CRF2receptors respectively). Attenuates CRF-induced activation of the HPA axisin vivofollowing i.v. administration. Orally active. | [Uses]
CP 376395 hydrochloride is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist[1][2]. | [in vivo]
CP 376395 (10-20 mg/kg, i.p., Male B6 mice) attenuates H2O and food intake, increases sucrose intake, attenuates EtOH intake but not EtOH preference[2]. | Animal Model: | Male B6 mice (n=8-9 per group)[2] | | Dosage: | 0.0, 10.0, or 20.0 mg/kg | | Administration: | Intraperitoneally | | Result: | Dose-dependently attenuated intake of H2O and food, with H2O intake affected specifically during the first half of the session. |
| [IC 50]
CRFR1; CRFR2 | [storage]
Desiccate at RT | [References]
[1] Chen YL, et al. 2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J Med Chem. 2008 Mar 13;51(5):1385-92. DOI:10.1021/jm070579c
[2] Giardino WJ, et al. CRF1 receptor signaling regulates food and fluid intake in the drinking-in-the-dark model of binge alcohol consumption. Alcohol Clin Exp Res. 2013 Jul;37(7):1161-70. DOI:10.1111/acer.12076 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|