| Identification | Back Directory | [Name]
Thieno[3,2-d]pyriMidin-4-aMine, N-[(1S)-2-[4-[(3,4-dichlorophenyl)sulfonyl]-1-piperazinyl]-1-Methylethyl]-7-Methyl- | [CAS]
1017606-66-4 | [Synonyms]
CS-1271
LPA2-IN-1
LPA2 antagonist 1
N-[(2S)-1-[4-(3,4-Dichlorophenyl)sulfonylpiperazin-1-yl]propan-2-yl]-7-methylthieno[3,2-d]pyrimidin-4-amine
Thieno[3,2-d]pyriMidin-4-aMine, N-[(1S)-2-[4-[(3,4-dichlorophenyl)sulfonyl]-1-piperazinyl]-1-Methylethyl]-7-Methyl- | [Molecular Formula]
C20H23Cl2N5O2S2 | [MDL Number]
MFCD28716107 | [MOL File]
1017606-66-4.mol | [Molecular Weight]
500.46 |
| Chemical Properties | Back Directory | [Boiling point ]
684.6±65.0 °C(Predicted) | [density ]
1.453±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/ml | [form ]
Powder | [pka]
6.52±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
LPA2 antagonist 1 is an antagonist of lysophosphatidic acid receptor 2 (LPA2; IC50 = 17 nM). It is selective for LPA2 over LPA1 and LPA3 (IC50s = >50 μM). LPA2 antagonist 1 inhibits HGF-induced phosphorylation of ERK and proliferation of HCT116 colon cancer cells in a concentration-dependent manner. | [Uses]
N-[(2S)-1-[4-(3,4-Dichlorophenyl)sulfonylpiperazin-1-yl]propan-2-yl]-7-methylthieno[3,2-d]pyrimidin-4-amine is a Lpa2 protein antagonists. | [storage]
Store at -20°C | [References]
[1] HILARY P. BECK . Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents[J]. Bioorganic & Medicinal Chemistry Letters, 2008, 18 3: Pages 1037-1041. DOI: 10.1016/j.bmcl.2007.12.024 |
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| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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