| Identification | Back Directory | [Name]
Acetamide, 2-amino-N-[4-chloro-2-(1H-pyrrol-2-ylcarbonyl)phenyl]- | [CAS]
106410-13-3 | [Synonyms]
GCPK
NSC140873
NSC-140873
NSC 140873
NSC 140873,NSC140873
Acetamide, 2-amino-N-[4-chloro-2-(1H-pyrrol-2-ylcarbonyl)phenyl]- | [Molecular Formula]
C13H12ClN3O2 | [MDL Number]
MFCD00951251 | [MOL File]
106410-13-3.mol | [Molecular Weight]
277.71 |
| Hazard Information | Back Directory | [Uses]
NSC 140873 is an inhibitor of the RUNX1-CBFβ interaction. NSC 140873 can be used for research of viral infection and leukemia. NSC 140873 has an unstable structure and can be converted spontaneously in solution to a benzodiazepine (Ro5-3335)[1][2]. | [References]
[1] Pu Liu, et al. Methods for treating leukemia and disorders mediated by cbfβ and runx1 proteins. Patent. WO2012125787A1.
[2] Cunningham L, et al. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14592-7. DOI:10.1073/pnas.1200037109 |
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