| Identification | Back Directory | [Name]
E3 ligase Ligand 14 | [CAS]
2241489-43-8 | [Synonyms]
E3 ligase Ligand 14 | [Molecular Formula]
C38H52N4O7 | [MDL Number]
MFCD32197260 | [Molecular Weight]
676.84 |
| Hazard Information | Back Directory | [Uses]
E3 ligase Ligand 14 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 14 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1]. | [IC 50]
IAP | [References]
[1] Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575. DOI:10.1021/acs.jmedchem.7b00168 |
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