| Identification | Back Directory | [Name]
rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine | [CAS]
1225383-33-4 | [Synonyms]
rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine
L-Leucine, N-[(2S,3R)-3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2-hydroxy-1-oxo-4-phenylbutyl]- | [Molecular Formula]
C31H34N2O6 | [MDL Number]
MFCD32197317 | [MOL File]
1225383-33-4.mol | [Molecular Weight]
530.61 |
| Chemical Properties | Back Directory | [Boiling point ]
815.8±65.0 °C(Predicted) | [density ]
1.252±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.37±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 8 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1]. | [IC 50]
IAP | [References]
[1] Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575. DOI:10.1021/acs.jmedchem.7b00168 |
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