| Identification | Back Directory | [Name]
3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine | [CAS]
111669-25-1 | [Synonyms]
BUTTPARK 46\04-67
1-Boc-4-(3-Aminopyridin-2-yl)
1-Boc-4-(3-aMinopyridin-2-yl)piperazine
3-AMINO-2-[4-BUTOXYCARBONYL(PIPERAZINO)]PYRIDINE
butyl 4-(3-aminopyridin-2-yl)piperazine-1-carboxylate
3-Amino-2-[4-tert-butoxycarbonyl(piperazino)]pyridine
tert-butyl 4-(3-amino-2-pyridyl)piperazine-1-carboxylate
ert-butyl4-(3-aminopyridin-2-yl)piperazine-1-carboxylate
tert-butyl 4-(3-aminopyridin-2-yl)piperazine-1-carboxylate
3-Amino-2-[4-tert-butoxycarbonyl(piperazino)]pyridine ,97%
1-(TERT-BUTYLOXYCARBONYL)-4-(3-AMINOPYRIDIN-2-YL)PIPERAZINE
4-(3-amino-2-pyridinyl)-1-piperazinecarboxylic acid butyl ester
1-Piperazinecarboxylic acid, 4-(3-amino-2-pyridinyl)-, 1,1-dimethylethyl ester | [EINECS(EC#)]
200-528-9 | [Molecular Formula]
C14H22N4O2 | [MDL Number]
MFCD03407996 | [MOL File]
111669-25-1.mol | [Molecular Weight]
278.35 |
| Chemical Properties | Back Directory | [Boiling point ]
448.8±45.0 °C(Predicted) | [density ]
1.182±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
9.35±0.29(Predicted) |
| Hazard Information | Back Directory | [Chemical Properties]
Grey to purple powder | [Synthesis]
Tert-butyl 4-(3-nitropyridin-2-yl)piperazine-1-carboxylate (350 mg, 1.14 mmol) was used as a raw material and mixed with Pd/C (60.4 mg, 10% w/w, 0.0568 mmol) and methanol (6 mL). The hydrogenation reaction was carried out at room temperature using a hydrogen balloon to provide a hydrogen atmosphere. The reaction mixture was stirred for 2 h and then filtered through diatomaceous earth to remove the catalyst. The filtrate was concentrated under reduced pressure and purified by silica gel column chromatography (eluent ratio hexane/EtOAc/CH2Cl2 = 1:1:1) to afford the target product tert-butyl 4-(3-aminopyridin-2-yl)piperazine-1-carboxylate (246 mg, 78% yield) as a white powder. Mass spectrometry (EI) analysis resulted in a molecular ion peak (MH+) of 279.2 for C14H22N4O2. | [References]
[1] Journal of Medicinal Chemistry, 1994, vol. 37, # 7, p. 999 - 1014
[2] Patent: WO2012/61337, 2012, A1. Location in patent: Page/Page column 45
[3] Patent: WO2008/112440, 2008, A1. Location in patent: Page/Page column 38-39
[4] Chemical and Pharmaceutical Bulletin, 2001, vol. 49, # 11, p. 1406 - 1411
[5] Journal of Labelled Compounds and Radiopharmaceuticals, 2011, vol. 54, # 7, p. 363 - 366 |
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