| Identification | Back Directory | [Name]
WAY 181187 | [CAS]
554403-49-5 | [Synonyms]
SAX-187
WAY 181187
WAY181187 HCl
WAY-181187(SAX-187)
WAY181187 hydrochloride
WAY181187.HCl(WAY-181,187)
SAX-187;WAY 181187;WAY-181187(SAX-187);WAY181187 HYDROCHLORIDE
1H-Indole-3-ethanamine, 1-[(6-chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl]- | [Molecular Formula]
C15H13ClN4O2S2 | [MDL Number]
MFCD09833239 | [MOL File]
554403-49-5.mol | [Molecular Weight]
380.87 |
| Chemical Properties | Back Directory | [density ]
1.67±0.1 g/cm3(Predicted) | [solubility ]
DMSO: Soluble: =10 mg/ml | [form ]
Solid | [pka]
9.30±0.10(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
WAY-181187 (SAX-187) is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM[1]. WAY181187 mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[2]. | [in vivo]
Acute administration of WAY-181187 (3-30 mg/kg, s.c.) significantly increases extracellular GABA concentrations without altering the levels of glutamate or norepinephrine in the rat frontal cortex. Additionally, WAY-181187 (30 mg/kg, s.c.) produces modest yet significant decreases in cortical dopamine and 5-HT levels[1]. | Animal Model: | Adult male Sprague-Dawley rats weighing 280–350 g[1] | | Dosage: | 3, 10, or 30 mg/kg | | Administration: | Acute dministered by s.c. | | Result: | Significantly increased extracellular GABA concentrations without altering the levels of glutamate or norepinephrine. |
| [IC 50]
5-HT6 Receptor: 2.2 nM (Ki); 5-HT6 Receptor: 6.6 nM (EC50) | [References]
[1] Lee E Schechter, et al. Neuropharmacological Profile of Novel and Selective 5-HT6 Receptor Agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33(6):1323-35. DOI:10.1038/sj.npp.1301503
[2] Teresa Riccioni, et al. ST1936 Stimulates cAMP, Ca2+, ERK1/2 and Fyn Kinase Through a Full Activation of Cloned Human 5-HT6 Receptors. Eur J Pharmacol. 2011 Jul 1;661(1-3):8-14. DOI:10.1016/j.ejphar.2011.04.028 |
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D&C Chemicals
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+86-21-58447131 |
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www.chemicalbook.com/ShowSupplierProductsList16963/0_EN.htm |
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