| Identification | Back Directory | [Name]
Bromo-PEG6-azide | [CAS]
2062663-64-1 | [Synonyms]
Br-PEG6-N3
Azido-PEG6-Br
Bro-PEG7-azido
Bromo-PEG6-azide
N3-PEG6-CH2CH2Br
1-?Azido-?20-?bromo-?3,?6,?9,?12,?15,?18-?hexaoxaicosane | [Molecular Formula]
C14H29BrN3O6+ | [MDL Number]
MFCD30536155 | [MOL File]
2062663-64-1.mol | [Molecular Weight]
415.301 |
| Hazard Information | Back Directory | [Description]
Bromo-PEG6-azide consist of a bromide(Br), a terminal azide(N3) and a PEG6 spacer. PEG spacer increases solubility in aqueous media. The bromide (Br) is a good leaving group for nucleophilic substitution. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. | [Uses]
Bromo-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromo-PEG6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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