| Identification | Back Directory | [Name]
Bromo-PEG6-t-butyl ester | [CAS]
1393330-41-0 | [Synonyms]
Br-PEG6-COOtBu
Bromo-PEG6-Boc
Br-PEG6-t-butyl
CAS_1393330-41-0
Br-PEG6-CH2CH2COOtBu
Br-PEG6-t-butyl ester
Bromo-PEG6-t-butyl ester
Bromo-PEG7-t-butyl ester
tert-butyl 1-bromo-3,6,9,12,15,18-hexaoxahenicosan-21-oate
4,7,10,13,16,19-Hexaoxaheneicosanoic acid, 21-bromo-, 1,1-dimethylethyl ester | [Molecular Formula]
C19 H37 Br O8 | [MDL Number]
MFCD22574809 | [MOL File]
1393330-41-0.mol | [Molecular Weight]
473.4 |
| Chemical Properties | Back Directory | [Boiling point ]
489.9±40.0 °C(Predicted) | [density ]
1.192±0.06 g/cm3(Predicted) | [form ]
Liquid | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C19H37BrO8/c1-19(2,3)28-18(21)4-6-22-8-10-24-12-14-26-16-17-27-15-13-25-11-9-23-7-5-20/h4-17H2,1-3H3 | [InChIKey]
MCRDORXGTMATBG-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)CCOCCOCCOCCOCCOCCOCCBr |
| Hazard Information | Back Directory | [Description]
Bromo-PEG6-t-butyl ester is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Bromo-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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