1193111-39-5

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1193111-39-5 Structure

Identification	Back Directory
[Name] Butanoic acid, 4-(2-pyridinyldithio)-2-sulfo-, 1-(2,5-dioxo-1-pyrrolidinyl) ester
[CAS] 1193111-39-5
[Synonyms] sulfo-SPDB Butanoic acid, 4-(2-pyridinyldithio)-2-sulfo-, 1-(2,5-dioxo-1-pyrrolidinyl) ester 1-(2,5-Dioxopyrrolidin-1-yloxy)-1-oxo-4-(pyridin-2-yldisulfanyl)butane-2-sulfonic acid
[Molecular Formula] C13H14N2O7S3
[MDL Number] MFCD20227457
[MOL File] 1193111-39-5.mol
[Molecular Weight] 406.45

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H302-H319
[Precautionary statements ] P305+P351+P338

Hazard Information	Back Directory
[Uses] sulfo-SPDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
[IC 50] Disulfide Cleavable Linker; Cleavable Linker
[References] [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

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