| Identification | Back Directory | [Name]
N3-PEG8-CH2CH2COOH | [CAS]
1214319-92-2 | [Synonyms]
N3-PEG8-COOH
1214319-92-2
Azido-dPEG??-acid
N3-PEG8-CH2CH2COOH
Azido-dPEG(R)8-acid
Azido-PEG8-propionic acid | [Molecular Formula]
C19H37N3O10 | [MDL Number]
MFCD21363300 | [MOL File]
1214319-92-2.mol | [Molecular Weight]
467.511 |
| Hazard Information | Back Directory | [Description]
Azido-PEG8-acid is a aqueous soluble PEG linker containing an azide (N3) and a terminal carboxylic acid (CO2H) group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [reaction suitability]
reaction type: click chemistry
reagent type: cross-linking reagent
reaction type: click chemistry | [Biological Activity]
N3-PEG8-CH2CH2COOH is a non-cleavable ADC linker containing 8-unit PEG that can be used to synthesize antibody drug conjugates (ADCs). It is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules. | [target]
| Non-cleavable < span> | PEGs | |
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