| Identification | Back Directory | [Name]
1-isothiocyanato-PEG3-Azide | [CAS]
1310686-23-7 | [Synonyms]
1-isothiocyanato-PEG3-Azide
1-Isothiocyanato PEG3-alcohol | [Molecular Formula]
C9H16N4O3S | [MDL Number]
MFCD29052172 | [MOL File]
1310686-23-7.mol | [Molecular Weight]
260.31 |
| Hazard Information | Back Directory | [Uses]
1-Isothiocyanato-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 1-Isothiocyanato-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [Biological Activity]
1-Isothiocyanato-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
|
|