| Identification | Back Directory | [Name]
Azido-PEG3-Maleimide | [CAS]
1858264-36-4 | [Synonyms]
N3-PEG3-Mal
Azide-PEG3-maleimide
Azido-PEG3-Maleimide | [Molecular Formula]
C15H23N5O6 | [MDL Number]
MFCD22380764 | [MOL File]
1858264-36-4.mol | [Molecular Weight]
369.373 |
| Hazard Information | Back Directory | [Description]
Azido-PEG3-Maleimide is provided as a kit of two vials. Azido-PEG3-Maleimide is not stable for storage; it needs to be made in situ by mixing Azido-PEG3-amine and Maleimide-NHS ester followed by shaking/ stirring for 30 minutes at room temperature. The maleimide group of the Azido-PEG3-Maleimide can react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. Azide group enables Click Chemsitry reactions. | [Biological Activity]
Azido-PEG3-maleimide is a PROTAC linker belonging to the PEG class, which can be used to synthesize PROTAC molecules. Azido-PEG3-maleimide is also a cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADCs). | [in vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
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Tags:1858264-36-4
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