| Identification | Back Directory | [Name]
Azido-PEG7-acid | [CAS]
361189-66-4 | [Synonyms]
N3-PEG6-COOH
Azido-PEG7-acid
Azido-PEG6-Acid
Azido-PEG6-propionic acid
Azido-PEG6-acid,N3-PEG6-acid
1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid | [Molecular Formula]
C15H29N3O8 | [MDL Number]
MFCD22056306 | [MOL File]
361189-66-4.mol | [Molecular Weight]
379.41 |
| Chemical Properties | Back Directory | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C15H29N3O8/c16-18-17-2-4-22-6-8-24-10-12-26-14-13-25-11-9-23-7-5-21-3-1-15(19)20/h1-14H2,(H,19,20) | [InChIKey]
KQYQHDQBMAJDRL-UHFFFAOYSA-N | [SMILES]
C(OCCOCCC(=O)O)COCCOCCOCCOCCN=[N+]=[N-] |
| Hazard Information | Back Directory | [Description]
Azido-PEG6-acid is a aqueous soluble PEG linker containing an azide and a terminal carboxylic acid. The azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
Azido-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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