| Identification | Back Directory | [Name]
Benzyl-PEG2-Azide | [CAS]
1260001-87-3 | [Synonyms]
Benzyl-PEG2-N3
CAS_1260001-87-3
Benzyl-PEG2-Azide
2-(2-azidoethoxy)ethoxymethylbenzene | [Molecular Formula]
C11H15N3O2 | [MDL Number]
MFCD28064332 | [MOL File]
1260001-87-3.mol | [Molecular Weight]
221.26 |
| Hazard Information | Back Directory | [Description]
Benzyl-PEG2-azide is a PEG linker with an acid labile, benzyl protecting group. The azide can participate in copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN moieties. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. | [Uses]
Benzyl-PEG2-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Benzyl-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [References]
[1] Steinebach C, et al. A MedChem toolbox for cereblon-directed PROTACs. Medchemcomm. 2019 May 28;10(6):1037-1041. DOI:10.1039/c9md00185a |
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