| Identification | Back Directory | [Name]
Biotin-PEG4-Alkyne | [CAS]
1262681-31-1 | [Synonyms]
1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-2-oxo-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl-, (3aS,4S,6aR)-
5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)pentanamide | [Molecular Formula]
C21H35N3O6S | [MOL File]
1262681-31-1.mol | [Molecular Weight]
457.58 |
| Chemical Properties | Back Directory | [Melting point ]
55-64 °C | [Boiling point ]
707.1±60.0 °C(Predicted) | [density ]
1.158±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
good in water, DMSO, DCM, DMF | [form ]
solid | [pka]
13.90±0.40(Predicted) | [color ]
Off-white to light yellow | [Appearance]
White or light grey solid binding | [InChIKey]
SKMJWNZZFUDLKQ-QWFCFKBJSA-N | [SMILES]
O=C(NCCOCCOCCOCCOCC#C)CCCC[C@@H](SC1)[C@@]2([H])[C@]1([H])NC(N2)=O |
| Hazard Information | Back Directory | [Description]
Biotin-PEG4-alkyne is a click chemistry biotinylation tool. This reagent allows the labeling of azide-containing molecules with biotin via copper-catalyzed click reaction. Biotin-labeled biomolecules can be bound to avidin or streptavidin for further purification and detection.
This structure of biotin alkyne features a long hydrophilic PEG4 linker that separates biotin residue from the target molecule for efficient binding with streptavidin. Its linker also enhances aqueous solubility to facilitate conjugation. | [Uses]
Biotin-PEG4-alkyne may be used for the modification of 4-azidophenylalanine (AzPhe) silk fibroin via bioorthogonal azide–alkyne cycloaddition reaction for developing photopatternable protein material. | [reaction suitability]
reaction type: click chemistry |
|
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Sigma-Aldrich
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