| Identification | Back Directory | [Name]
BocNH-PEG6-CH2CH2N3 | [CAS]
1292268-15-5 | [Synonyms]
Azido-PEG6-NHBoc
Boc-NH-PEG6-azide
BocNH-PEG6-CH2CH2N3 | [Molecular Formula]
C19H38N4O8 | [MDL Number]
MFCD30723224 | [MOL File]
1292268-15-5.mol | [Molecular Weight]
450.53 |
| Hazard Information | Back Directory | [Description]
t-boc-N-amido-PEG6-azide is a azide containing crosslinking reagent with a Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The reagent can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine. | [Uses]
Boc-NH-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-NH-PEG6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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