| Identification | Back Directory | [Name]
Azide-PEG6-Tos | [CAS]
906007-10-1 | [Synonyms]
N3-PEG6-Tos
Azido-PEG6-OTs
Azido-PEG6-Tos
Azide-PEG6-Tos
2[-2-(2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]- ethyl p-tosylate | [Molecular Formula]
C19H31N3O8S | [MDL Number]
MFCD29918254 | [MOL File]
906007-10-1.mol | [Molecular Weight]
461.53 |
| Hazard Information | Back Directory | [Description]
Azide-PEG6-Tos consist of an azide group and a tosyl group. 6 PEG units increases solubility in aqueous media. The azide(N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The tosyl group is a good leaving group for nucleophilic substitution reactions. | [Uses]
Azide-PEG6-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG6-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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