| Identification | Back Directory | [Name]
VU-29 | [CAS]
890764-36-0 | [Synonyms]
VU-29
N-(1,3-Diphenyl-1H-pyrazol-5-yl)-4-nitrobenzamide
N-(1,3-Diphenyl-1H-pyrazolo-5-yl)-4-nitrobenzamide
BenzaMide, N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-nitro- | [Molecular Formula]
C22H16N4O3 | [MDL Number]
MFCD12546140 | [MOL File]
890764-36-0.mol | [Molecular Weight]
384.39 |
| Chemical Properties | Back Directory | [Melting point ]
221-223℃ | [Boiling point ]
545.0±45.0 °C(Predicted) | [density ]
1.30 | [storage temp. ]
Store at RT | [solubility ]
Soluble to 100 mM in DMSO | [form ]
Powder | [pka]
11.17±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
DPAP is a potent, postive allosteric, potentiator at mGluR-5. | [in vivo]
VU-29 (500 nM) potentiates DHPG induced increases in phosphoinositide (PI) hydrolysis in rat hippocampal slices. VU-29 potentiates threshold TBS-induced long term potentiation (LTP) in rat hippocampal CA1 region. VU-29 (1 μM) potentiates chemically induced mGluR-long term depression (LTD) in area CA1 of the rat hippocampus. VU-29 (1 μM) potentiates stimulus-induced NMDA receptor-independent LTD[1]. | [IC 50]
rat mGluR5: 9 nM (EC50); rat mGluR1: 557 nM (EC50); rat mGluR2: 1.5 μM (EC50); hmGluR4: 154 nM (EC50); rat mGluR5: 224 nM (Ki) | [storage]
Store at RT |
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