| Identification | Back Directory | [Name]
Acid-PEG5-t-butyl ester | [CAS]
1309460-29-4 | [Synonyms]
COOH-PEG5-OtBu
COOH-PEG5-COOtBu
Acid-PEG5-C2-Boc
Acid-PEG5-t-butyl ester
HOOCCH2CH2O-PEG4-CH2CH2COOtBu
4,7,10,13,16-Pentaoxanonadecanedioic acid, 1-(1,1-dimethylethyl) ester | [Molecular Formula]
C18H34O9 | [MDL Number]
MFCD18916989 | [MOL File]
1309460-29-4.mol | [Molecular Weight]
394.46 |
| Chemical Properties | Back Directory | [Boiling point ]
495.2±45.0 °C(Predicted) | [density ]
1.109±0.06 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [pka]
4.28±0.10(Predicted) | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C18H34O9/c1-18(2,3)27-17(21)5-7-23-9-11-25-13-15-26-14-12-24-10-8-22-6-4-16(19)20/h4-15H2,1-3H3,(H,19,20) | [InChIKey]
ILIIUHKWCBCCNI-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)CCOCCOCCOCCOCCOCCC(O)=O |
| Hazard Information | Back Directory | [Description]
Acid-PEG5-t-butyl ester is a PEG linker containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Acid-PEG5-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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| Company Name: |
Shanghai Uchem Inc.
|
| Telephone: |
15618758386 15618758386 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList15300/0_EN.htm |
| Company Name: |
Nextpeptide Inc
|
| Telephone: |
+86-0571-81612335 +8613336028439 |
| Website: |
http://www.nextpeptide.com/ |
|