| Identification | Back Directory | [Name]
Acid-PEG6-t-butyl ester | [CAS]
2093153-84-3 | [Synonyms]
COOH-PEG6-OtBu
COOH-PEG6-COOtBu
Acid-PEG6-C2-Boc
Acid-PEG6-t-butyl ester
HOOCCH2CH2O-PEG5-CH2CH2COOtBu | [Molecular Formula]
C20H38O10 | [MDL Number]
MFCD30723271 | [MOL File]
2093153-84-3.mol | [Molecular Weight]
438.51 |
| Chemical Properties | Back Directory | [Boiling point ]
528.9±50.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [pka]
4.28±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Acid-PEG6-t-butyl ester is a PEG linker containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Acid-PEG6-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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