| | Identification | Back Directory |  | [Name] 
 Ald-Ph-PEG3-Azide
 |  | [CAS] 
 1807540-88-0
 |  | [Synonyms] 
 DF-PEG3-N3
 ALD-PH-PEG3-N3
 CHO-Ph-PEG3-azide
 Ald-Ph-PEG3-Azide
 CHO-Ph-CONH-PEG3-azide
 Ald-Ph-amido-C2-PEG3-azide
 |  | [Molecular Formula] 
 C16H22N4O5
 |  | [MDL Number] 
 MFCD28155209
 |  | [MOL File] 
 1807540-88-0.mol
 |  | [Molecular Weight] 
 350.38
 | 
 | Hazard Information | Back Directory |  | [Description] 
 Ald-Ph-PEG3-azide is a PEG reagent containing a benzaldehyde group and a terminal azide group. The benzaldehyde can react with primary amines. The azide can react with alkynes, DBCO and BCN moieties via Click Chemistry reactions.
 |  | [Uses] 
 Ald-Ph-amido-C2-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Ald-Ph-amido-C2-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
 |  | [IC 50] 
 PEGs
 |  | [References] 
 [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
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