| Identification | Back Directory | [Name]
LY-2812223) | [CAS]
1311385-20-2 | [Synonyms]
LY-2812223)
LY 2812223
(LY2812223
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-4-(1H-1,2,4-triazol-5-ylthio)-, (1R,2S,4R,5R,6R)- | [Molecular Formula]
C10H12N4O4S | [MDL Number]
MFCD30533467 | [MOL File]
1311385-20-2.mol | [Molecular Weight]
284.29 |
| Chemical Properties | Back Directory | [Boiling point ]
617.7±65.0 °C(Predicted) | [density ]
1.78±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Water: 50 mg/mL (175.88 mM); DMSO: 28.75 mg/mL (101.13 mM) | [form ]
Solid | [pka]
1.54±0.60(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
LY2812223 is a potent mGluR2-preferring agonist. | [Uses]
LY2812223 is a highly potent, functionally selective mGlu2 receptor agonist with mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively)[1]. | [IC 50]
mGluR2: 144 nM (Ki); mGluR3: 156 nM (Ki) | [References]
[1] Monn JA, et al. Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxy DOI:10.1021/acs.jmedchem.5b01124 |
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cjbscvictory
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13348960310 |
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https://www.weikeqi-biotech.com/ |
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