| Identification | Back Directory | [Name]
MGlu2 agonist | [CAS]
1311385-32-6 | [Synonyms]
MGlu2 agonist
LY-2979165;LY 2979165
LY2979165 Ammonium salt
Ammonium (1R,2S,4R,5R,6R)-4-((1H-1,2,4-triazol-5-yl)thio)-2-((S)-2-aminopropanamido)-2-carboxybicyclo[3.1.0]hexane-6-carboxylate hydrate
(1R,2S,4R,5R,6R)-2-[[(2S)-2-Amino-1-oxopropyl]amino]-4-(1H-1,2,4-triazol-5-ylthio)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid ammonium salt hydrate (1:1:1)
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-[[(2S)-2-aMino-1-oxopropyl]aMino]-4-(1H-1,2,4-triazol-5-ylthio)-, aMMoniuM salt, hydrate (1:1:1), (1R,2S,4R,5R,6R)-
(1R,2S,4R,5R,6R)-2-[[(2S)-2-Amino-1-oxopropyl]amino]-4-(1H-1,2,4-triazol-5-ylthio)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid ammonium salt hydrate (1:1:1) LY2979165 | [Molecular Formula]
C13H22N6O6S | [MOL File]
1311385-32-6.mol | [Molecular Weight]
390.415 |
| Hazard Information | Back Directory | [Uses]
LY2979165 is the alanine proagent of 2812223, a selective and potent orthosteric mGlu2 receptor agonist[1]. | [in vivo]
LY2979165 attenuated the ketamine-evoked BOLD phMRI signal in vivo[2]. | [IC 50]
mGlu2 Receptor | [storage]
Store at -20°C | [References]
[1] Juliet McColm , et al. Evaluation of Single and Multiple Doses of a Novel mGlu2 Agonist, a Potential Antipsychotic Therapy, in Healthy Subjects. Br J Clin Pharmacol. 2017 Aug;83(8):1654-1667. DOI:10.1111/bcp.13252
[2] Mitul A Mehta, et al. Group II metabotropic glutamate receptor agonist prodrugs LY2979165 and LY2140023 attenuate the functional imaging response to ketamine in healthy subjects. Psychopharmacology (Berl). 2018 Jul;235(7):1875-1886. DOI:10.1007/s00213-018-4877-9 |
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