| Identification | Back Directory | [Name]
Azido-PEG2-CH2CO2-NHS | [CAS]
1312309-64-0 | [Synonyms]
N3-PEG2-SPA
N3-PEG2-CH2CO2-NHS
N3-PEG2-C2-NHS ester
N3-PEG2-CH2CH2COONHS
Azido-PEG2-CH2CO2-NHS
N3-PEG2-CH2CH2COONHS Ester
2,5-dioxopyrrolidin-1-yl 3-(2-(2-azidoethoxy)ethoxy)propanoate
Propanoic acid, 3-[2-(2-azidoethoxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C11H16N4O6 | [MDL Number]
MFCD28142477 | [MOL File]
1312309-64-0.mol | [Molecular Weight]
300.27 |
| Hazard Information | Back Directory | [Description]
Azido-PEG2-NHS ester is a click chemistry crosslinker containing an azide group and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | [Uses]
N3-PEG2-C2-NHS ester is a nonclaevable 2-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG2-C2-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
Non-cleavable Linker |
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