| Identification | Back Directory | [Name]
YKL 06-061 | [CAS]
2172617-15-9 | [Synonyms]
YKL 06-061
YKL-06-061; YKL06-061; YKL 06-061; YKL-06061; YKL06061; YKL 06061
Pyrimido[4,5-d]pyrimidin-2(1H)-one, 1-cyclobutyl-3-(2,6-dimethylphenyl)-3,4-dihydro-7-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]- | [Molecular Formula]
C30H37N7O2 | [MDL Number]
MFCD32173438 | [MOL File]
2172617-15-9.mol | [Molecular Weight]
527.66 |
| Chemical Properties | Back Directory | [Boiling point ]
719.8±70.0 °C(Predicted) | [density ]
1.268±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C, protect from light, stored under nitrogen | [solubility ]
DMSO: 62.5 mg/mL (118.45 mM); Water: < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
7.76±0.42(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively[1]. | [IC 50]
SIK1 | [References]
[1] Mujahid N, et al. A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin. Cell Rep. 2017 Jun 13;19(11):2177-2184. DOI:10.1016/j.celrep.2017.05.042 |
|
|