| Identification | Back Directory | [Name]
Bis-PEG9-PFP ester | [CAS]
1334170-00-1 | [Synonyms]
Bis-PEG9-PFP ester
Bis-dPEG(R)9-PFP ester
Bis-dPEG(R)13-PFP ester
4,7,10,13,16,19,22,25,28-Nonaoxahentriacontanedioic acid, 1,31-bis(2,3,4,5,6-pentafluorophenyl) ester | [Molecular Formula]
C34H40F10O13 | [MDL Number]
MFCD20926401 | [MOL File]
1334170-00-1.mol | [Molecular Weight]
846.66 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO, DCM | [form ]
solid or viscous liquid | [InChIKey]
OFZQOXAQZALFLN-UHFFFAOYSA-N | [SMILES]
O=C(OC1=C(C(F)=C(C(F)=C1F)F)F)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(OC2=C(C(F)=C(C(F)=C2F)F)F)=O |
| Hazard Information | Back Directory | [Description]
Bis-PEG9-PFP ester is a PEG linker with two activated PFP ester moieties. PFP esters can react with amine groups to form amide bonds. They are also less susceptible to undergo hydrolysis compared to other amine reactive groups. The hydrophilic PEG linker increase the water solubility of the compond in aqueous media. | [Uses]
Bis-PEG9-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [reaction suitability]
reagent type: cross-linking reagent
reactivity: amine reactive | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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Sigma-Aldrich
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Nextpeptide Inc
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http://www.nextpeptide.com/ |
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Energy Chemical
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