| Identification | Back Directory | [Name]
Bromo-PEG4-acid | [CAS]
1393330-38-5 | [Synonyms]
Br-PEG-COOH
Br-PEG4-acid
Br-PEG4-COOH
Bromo-PEG4-acid
Bromo-PEG5-acid
CAS_1393330-38-5
Br-PEG4-CH2CH2COOH
Bromo-PEG4-propionic acid
Bromo-PEG4-acid,Bromo-PEG4-COOH
1-Bromo-3,6,9,12-tetraoxapentadecan-15-oic acid
Propanoic acid, 3-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]- | [Molecular Formula]
C11H21BrO6 | [MDL Number]
MFCD22574799 | [MOL File]
1393330-38-5.mol | [Molecular Weight]
329.18 |
| Chemical Properties | Back Directory | [Boiling point ]
426.9±40.0 °C(Predicted) | [density ]
1.352±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble in Water, DMSO, DMF, DCM | [form ]
Liquid | [pka]
4.28±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Bromo-PEG4-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
Bromo-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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