| Identification | Back Directory | [Name]
1H-Cyclopenta[b]benzofuran-2-carboxylic acid, 6-(aminocarbonyl)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-, methyl ester, (1R,2R,3S,3aR,8bS)- | [CAS]
1402931-71-8 | [Synonyms]
eIF4A3-IN-9
1H-Cyclopenta[b]benzofuran-2-carboxylic acid, 6-(aminocarbonyl)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-, methyl ester, (1R,2R,3S,3aR,8bS)- | [Molecular Formula]
C28H27NO8 | [MOL File]
1402931-71-8.mol | [Molecular Weight]
505.52 |
| Chemical Properties | Back Directory | [Boiling point ]
622.9±55.0 °C(Predicted) | [density ]
1.404±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
11.66±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
eIF4A3-IN-9 (compound 57) is a silvestrol (HY-13251) analogue. eIF4A3-IN-9 interferes the assembling of eIF4F translation complex with EC50s of 29, 450 and 80 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-9 can be used for the research of human cancer pathogenesis[1]. | [References]
[1] Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78. DOI:10.1021/jm3011542 |
|
|