| Identification | Back Directory | [Name]
4-Methoxy-3-[2-[(3-methoxy-4-morpholinophenyl)amino]-4-pyridyl]benzonitrile | [CAS]
1417795-25-5 | [Synonyms]
TINK-IN-1
4-Methoxy-3-[2-[(3-methoxy-4-morpholinophenyl)amino]-4-pyridyl]benzonitrile | [Molecular Formula]
C24H24N4O3 | [MOL File]
1417795-25-5.mol | [Molecular Weight]
416.47 |
| Chemical Properties | Back Directory | [Boiling point ]
611.054±55.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.296±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
5.178±0.10(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TINK-IN-1 (Compound 9) is a potent and selective Traf2- and Nck-interacting kinase (TNIK) inhibitor with an IC50 of 8 nM. TINK-IN-1 inhibits colorectal cancer cells viability[1]. | [References]
[1] Ho KK, et al. Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors. Bioorg Med Chem Lett. 2013 Jan 15;23(2):569-73. DOI:10.1016/j.bmcl.2012.11.013 |
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