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1422540-92-8

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1422540-92-8 Structure

1422540-92-8 Structure
IdentificationBack Directory
[Name]

HC≡C-CH2-PEG8-SH
[CAS]

1422540-92-8
[Synonyms]

HC≡C-CH2-PEG8-SH
Propargyl-PEG8-SH
[Molecular Formula]

C19H36O8S
[MDL Number]

MFCD31747072
[MOL File]

1422540-92-8.mol
[Molecular Weight]

424.55
Chemical PropertiesBack Directory
[Boiling point ]

490.3±45.0 °C(Predicted)
[density ]

1.086±0.06 g/cm3(Predicted)
[pka]

9?+-.0.10(Predicted)
Hazard InformationBack Directory
[Uses]

Propargyl-PEG8-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG8-SH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
[Biological Activity]

Propargyl-PEG8-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[IC 50]

PEGs
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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