| Identification | Back Directory | [Name]
Propargyl-PEG8-acid | [CAS]
2055014-94-1 | [Synonyms]
CAS_2055014-94-1
Propargyl-PEG8-acid
Propargyl-PEG7-CH2CH2COOH
4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid | [Molecular Formula]
C20H36O10 | [MDL Number]
MFCD28976699 | [MOL File]
2055014-94-1.mol | [Molecular Weight]
436.49 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C, stored under nitrogen | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG8-acid has an alkyne group and an acid group. The acid group can derivatize amine-containing molecules in the presence of activators such as EDC or HATU. The alkyne group can react with azides via copper catalyzed Click Chemistry reactions. The PEG units help increase the solubility of the molecule in aqueous environment. | [Uses]
Propargyl-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The ADCs can be used in bacterial infections caused by Gram-negative bacteria[1]. Propargyl-PEG8-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Cleavable Linker; PEGs | [References]
[1] Suzanne AKERS-RODRIGUEZ, et al. Compositions and methods for the treatment of bacterial infections. WO2019126353A2. |
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