| Hazard Information | Back Directory | [Description]
IND81 is an antiprion agent. It acts by extending the lives of prion-infected animals. | [Uses]
IND81 is an orally active antiprion with IC50 value of 1.95 μM. IND81 reduces abnormal, misfolded, disease-causing forms of benign prion proteins that are normally present on or within cells[1]. | [References]
[1] Silber BM, et al. Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Pharm Res. 2013 Apr;30(4):932-50. DOI:10.1007/s11095-012-0912-4 |
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