| Identification | More | [Name]
Benserazide hydrochloride | [CAS]
14919-77-8 | [Synonyms]
2'-(2,3,4-trihydroxybenzyl)-dl-serinohydrazide monohydrochloride
BENSERAZIDE HCL
BENSERAZIDE HYDROCHLORIDE
DL-SERINE 2-[(2,3,4-TRIHYDROXYPHENYL)METHYL]HYDRAZIDE HCL
DL-SERINE 2[(2,3,4-TRIHYDROXYPHENYL)-METHYL] HYDRAZIDE HYDROCHLORIDE
RO 4-4602
2-(2,3,4-trihydroxybenzyl)hydrazide,monohydrochloride,dl-serin
dl-serine,2-((2,3,4-trihydroxyphenyl)methyl)hydrazide,monohydrochloride
dl-serine2-(2,3,4-trihydroxybenzyl)hydrazinehydrochloride
BENSERAZIDE HYDROCHLORIDE EP2000
BENSERAZIDE HYDROCHLORIDE \ PERIPHERAL D
dl-serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride
BENPARIZDE
DL-Serine N2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride
N'-(DL-Seryl)-N''-(2,3,4-trihydroxybenzyl)hydrazine hydrochloride
N-(DL-Seryl)-N'-(2,3,4-trihydroxybenzyl)hydrazine hydrochloride
Ro 4-4602/001
Serine, 2-(2,3,4-trihydroxybenzyl)hydrazide, monohydrochloride (8CI)
Serine, 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide, monohydrochloride
2-(2,3,4-TRIHYDROXYBENZYL)HYDRAZIDE | [EINECS(EC#)]
238-991-9 | [Molecular Formula]
C10H16ClN3O5 | [MDL Number]
MFCD00078571 | [Molecular Weight]
293.7 | [MOL File]
14919-77-8.mol |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Solid | [Melting point ]
146°C | [storage temp. ]
2-8°C | [solubility ]
H2O: 10 mg/mL
| [form ]
solid
| [color ]
White to Off-White | [PH]
pH(10g/L, 25℃) : 4.0～5.0 | [biological source]
synthetic | [Water Solubility ]
Soluble in water, dimethyl sulfoxide and methanol. Insoluble in ethanol and acetone. | [Sensitive ]
Light Sensitive | [Usage]
Used as antiparkinsonian. A peripheral decarboxylase inhibitor | [λmax]
272nm(HCl aq.)(lit.) | [Merck ]
14,1050 | [InChI]
InChI=1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H | [InChIKey]
ULFCBIUXQQYDEI-UHFFFAOYSA-N | [SMILES]
C(NNCC1=CC=C(O)C(O)=C1O)(=O)C(CO)N.[H]Cl | [CAS DataBase Reference]
14919-77-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
2
| [RTECS ]
VT9632300
| [HS Code ]
29280000 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
Benserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC), an enzyme that has dopamine decarboxylase activity.1,2 It is also unable to cross the blood-brain barrier. As a result, benserazide blocks the conversion of L-DOPA (Item No. 13248) to dopamine by AADC in the peripheral circulatory system. Benserazide is often combined with L-DOPA in patients with Parkinson’s disease.3 | [Chemical Properties]
White Crystalline Solid | [Uses]
Antiparkinsonian;DOPA decarboxylase inhibitor | [Uses]
Used as antiparkinsonian. A peripheral decarboxylase inhibitor | [Definition]
ChEBI: A hydrochloride that is the monohydrochloride salt of benserazide. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as an adjunct to levodopa in the treatment of park
nsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide hydrochloride has no antiparkinson actions whe
given alone. | [General Description]
Benserazide is a peripheral decarboxylase inhibitor. | [Biochem/physiol Actions]
Inhibitor of L-aromatic amino acid decarboxylase. | [References]
[1] SCHULTZ E. L-dopa as Substrate for human duodenal catechol-O-methyltransferase and aromatic L-amino acid decarboxylase[J]. Biomedical Chromatography, 1990, 4 6: 242-244. DOI: 10.1002/bmc.1130040607
[2] BENDER D A. Inhibition in vitro of the enzymes of the oxidative pathway of tryptophan metabolism and of nicotinamide nucleotide synthesis by benserazide, carbidopa and isoniazid[J]. Biochemical pharmacology, 1980, 29 5: Pages 707-712. DOI: 10.1016/0006-2952(80)90544-4
[3] WEI LI. Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2.[J]. ACS Chemical Biology, 2017: 58. DOI: 10.1186/s13046-017-0530-4
[4] HUO SHEN . Effects of benserazide on l-DOPA-derived extracellular dopamine levels and aromatic l-amino acid decarboxylase activity in the striatum of 6-hydroxydopamine-lesioned rats[J]. International congress series, 2003, 1251: Pages 199-204. DOI: 10.1016/s0531-5131(03)00119-5 |
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