| Identification | Back Directory | [Name]
SP100030 analogue 1 | [CAS]
154934-68-6 | [Synonyms]
SP100030 analogue 1
5-Pyrimidinecarboxamide, 2-chloro-N-[3-fluoro-5-(trifluoromethyl)phenyl]-4-(trifluoromethyl)- | [Molecular Formula]
C13H5ClF7N3O | [MOL File]
154934-68-6.mol | [Molecular Weight]
387.64 |
| Chemical Properties | Back Directory | [Boiling point ]
346.391±42.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.629±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
8.733±0.70(predicted) |
| Hazard Information | Back Directory | [Uses]
SP100030 analogue 1 (compound 11), a SP100030 (HY-110177) analogue, is a selective inhibitor of transcriptional activation (SITA) with an EC50 of 137 nM for suppressing the XPO1-dependent upregulation of IL2 by Jurkat-based IL2-Luc reporter assay[1]. | [References]
[1] Yi Fan Chen, et al. Electrophile Determines Cellular Phenotypes among XPO1-Targeting Small Molecules. J Med Chem. 2024 Jul 25;67(14):12033-12054. DOI:10.1021/acs.jmedchem.4c00754 |
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