| Identification | Back Directory | [Name]
BOS-172722 | [CAS]
1578245-44-9 | [Synonyms]
BOS-172722
BOS-172722 USP/EP/BP
N2-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine
Pyrido[3,4-d]pyrimidine-2,8-diamine, N8-(2,2-dimethylpropyl)-N2-[2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl]-6-methyl- | [Molecular Formula]
C24H30N8O | [MDL Number]
MFCD31692374 | [MOL File]
1578245-44-9.mol | [Molecular Weight]
446.55 |
| Chemical Properties | Back Directory | [Boiling point ]
672.2±65.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:5.0(Max Conc. mg/mL);11.19(Max Conc. mM)
1M HCl:65.0(Max Conc. mg/mL);145.56(Max Conc. mM) | [form ]
Solid | [pka]
5.83±0.30(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 11 nM and 63 nM for MPS1 (1 mM ATP) and P-MPS1, respectively. BOS-172722 also has potential for the study of various forms of breast cancer[1]. | [in vivo]
BOS-172722 shows excellent PK in mouse, rat, and dog[1].
BOS-172722 (50 mg/kg) results in an increased suppression of MPS1 autophosphorylation at 6 and 24 h[1].
| Animal Model: | Dog[2]. | | Dosage: | 1 mg/kg (iv), 5 mg/kg (po) (Pharmacokinetic Analysis). | | Administration: | IV and PO. | | Result: | T1/2 = 12 h, Cmaxpo = 7770 nmol/L, AUCpo = 147035 h*nmol/L. |
| [References]
[1] ARYL SULFONOHYDRAZIDES. WO 2014037750 A1. |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
|