| Identification | Back Directory | [Name]
DuocarMycin TM | [CAS]
157922-77-5 | [Synonyms]
CS-1380
DuocarMycin TM
1H-Benz[e]indol-5-ol, 1-(chloromethyl)-2,3-dihydro-3-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-, (1S)- | [Molecular Formula]
C25H23ClN2O5 | [MOL File]
157922-77-5.mol | [Molecular Weight]
466.91 |
| Chemical Properties | Back Directory | [Boiling point ]
711.7±60.0 °C(Predicted) | [density ]
1.389±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 50 mg/mL (107.09 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
9.43±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Duocarmycin TM (CBI-TMI) is a potent antitumor antibiotic. Duocarmycin TM induces a sequence-selective alkylation of duplex DNA. | [IC 50]
Duocarmycins | [References]
[1] Zhang D, et, al. Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads. Bioconjug Chem. 2018 Feb 21;29(2):267-274. DOI:10.1021/acs.bioconjchem.7b00576 |
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| Company Name: |
Abydos Scientific
|
| Tel: |
025-84767922 18936879710 |
| Website: |
www.abydoscientific.com/index.html |
| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
|