| Identification | Back Directory | [Name]
Corynoxine B | [CAS]
17391-18-3 | [Synonyms]
Corynoxine B
7-Isocorynoxine
Corynoxine B, 99.5%
(7R,16E)-17-Methoxy-2-oxo-20betaH-corynox-16-en-16-carbonsae
Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1'R,6'S,7'S,8'aS)- | [Molecular Formula]
C22H28N2O4 | [MDL Number]
MFCD22124999 | [MOL File]
17391-18-3.mol | [Molecular Weight]
384.48 |
| Chemical Properties | Back Directory | [Boiling point ]
560.8±50.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 83.33 mg/mL (216.74 mM) | [form ]
Solid | [pka]
13.61±0.60(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Chemical Properties]
White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the Rubiaceae plant Uncaria rhynchophylla. | [Uses]
Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin-1-dependent autophagy inducer. | [Definition]
ChEBI:Corynoxine B is a member of indolizines. It has a role as a metabolite. | [in vivo]
Corynoxine B (5-20 mg/kg, i.p.) enhances autophagy of alpha synuclein (alpha syn) clearance in Parkinson's disease mice by targeting HMGB1/2[3]. | Animal Model: | A53T α-syn transgenic mouse model[3]. | | Dosage: | 5-20 mg/kg | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Promoted α-syn clearance |
| [IC 50]
α-synuclein Aggregation | [storage]
Store at -20°C |
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