| Identification | Back Directory | [Name]
corynoxeine | [CAS]
630-94-4 | [Synonyms]
corynoxeine
Corynoxeine, 99.9%
corynoxeine USP/EP/BP
16,17,18,19-Tetradehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester
(7R,16E,20α)-16,17,18,19-Tetradehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester
Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-aceticacid, 6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-a-(methoxymethylene)-2-oxo-, methyl ester, (aE,1'R,6'R,7'S,8'aS)-
Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1'R,6'R,7'S,8'aS)-
(alphaE,1'R,6'R,7'S,8'aS)-6'-Ethenyl-1,2,2',3',6',7',8',8'a-octahydro-alpha-(methoxymethylene)-2-oxospiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid methyl ester | [Molecular Formula]
C22H26N2O4 | [MDL Number]
MFCD20527288 | [MOL File]
630-94-4.mol | [Molecular Weight]
382.46 |
| Chemical Properties | Back Directory | [Melting point ]
210℃ | [Boiling point ]
562.7±50.0 °C(Predicted) | [density ]
1.25 | [solubility ]
DMSO:27.87(Max Conc. mg/mL);72.87(Max Conc. mM) | [form ]
Powder | [pka]
13.54±0.60(Predicted) | [color ]
White to off-white | [InChIKey]
MUVGVMUWMAGNSY-VAUYTDFQNA-N | [SMILES]
O=C1NC2C=CC=CC=2[C@]21CCN1C[C@H](C=C)[C@@H](/C(=C\OC)/C(=O)OC)C[C@@]21[H] |&1:9,14,17,27,r| |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Uncaria rhynchophylla. | [Uses]
Corynoxeine is an alkaloid isolated from extraction of Uncaria rhynchophylla, is useful in the treatment of vascular diseases and protection against ischemia-induced neuronal damage. | [Synthesis]
Corynoxeine is extracted by refluxing Uncaria hooks with ethyl acetate for 2 h (×3), and the extract is separated on silica gel column and purified by high performance liquid chromatography (HPLC) to obtain dehydrocorynoxeine and isodehydrocorynoxeine, wh | [IC 50]
ERK1; ERK2 |
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