| Identification | Back Directory | [Name]
Corynoxine | [CAS]
6877-32-3 | [Synonyms]
Corynoxine
Corynoxine A
Corynoxine, 99.5%
(16E)-16,17-Didehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester
Corynoxan-16-carboxylicacid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (16E)-
Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1'S,6'S,7'S,8'aS)- | [EINECS(EC#)]
211-708-6 | [Molecular Formula]
C22H28N2O4 | [MDL Number]
MFCD09953806 | [MOL File]
6877-32-3.mol | [Molecular Weight]
384.47 |
| Chemical Properties | Back Directory | [Melting point ]
166-168℃ | [Boiling point ]
560.8±50.0 °C(Predicted) | [density ]
1.23 | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 100 mg/mL (260.10 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Cryst. | [pka]
13.61±0.60(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the Rubiaceae plant Uncaria rhynchophylla. | [Uses]
Corynoxine is an indole alkaloid extracted from Uncaria plants, and have been shown to affect locomotor response in mice . Research points to a mediation of the central dopaminergic system. | [Definition]
ChEBI: A natural product found in Uncaria macrophylla. | [in vivo]
Corynoxine (100-100 mg/kg; oral gavage) exhibits prolongation of the thiopental-induced hypnosis in mice[2].
Corynoxine (10-100 μM for 12 h) induces autophagy in drosophila[1]. | [target]
Akt | mTOR | Autophagy |
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China Langchem Inc.
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