| Identification | Back Directory | [Name]
Bromoacetamido-PEG2 -Boc-amine | [CAS]
182244-33-3 | [Synonyms]
Bromoacetamido-PEG2-NH-Boc
Bromoacetamido-C2-PEG2-NH-Boc
Bromoacetamido-PEG2 -Boc-amine
Bromoacetamido-PEG3-t-Boc-N-Amide
tert-Butyl (2-(2-(2-(2-bromoacetamido)ethoxy)ethoxy)ethyl)carbamate | [Molecular Formula]
C13H25BrN2O5 | [MDL Number]
MFCD28142467 | [MOL File]
182244-33-3.mol | [Molecular Weight]
369.25 |
| Chemical Properties | Back Directory | [Boiling point ]
506.5±50.0 °C(Predicted) | [density ]
1.285±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.23±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Bromoacetamido-PEG2-Boc-amine is a PEG linker containing a Boc protected amine and a bromide group. The protected amine can be deprotected under mild acidic conditions. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
Bromoacetamido-C2-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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