| Chemical Properties | Back Directory | [Boiling point ]
585.5±50.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 3 mg/ml; DMSO: Slightly soluble; Ethanol: Slightly soluble | [form ]
A solid | [pka]
14.53±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
SBI-553 is a potent and brain penetrant NTR1 allosteric modulator. | [Uses]
SBI-553 is a potent and brain penetrant NTR1 allosteric modulator, with an EC50 of 0.34 μM[1][2]. | [in vivo]
SBI-553 (12 mg/kg intraperitoneally administered) alleviates cocaine-or methamphetamine-induced hyperactivity in wild-type mice[2].
| [IC 50]
NTR1 | [storage]
Store at -20°C | [References]
[1] Pinkerton AB, et al. Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators. J Med Chem. 2019 Aug 20. DOI:10.1021/acs.jmedchem.9b00340
[2] Slosky LM, et al. β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors. Cell. 2020 Jun 11;181(6):1364-1379.e14. DOI:10.1016/j.cell.2020.04.053 |
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