1957235-99-2

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1957235-99-2 Structure

Identification	Back Directory
[Name] Thalidomide-O-C6-NH2 TFA
[CAS] 1957235-99-2
[Synonyms] Thalidomide-O-C6-NH2 TFA
[Molecular Formula] C21H24F3N3O7
[MDL Number] MFCD33398560
[MOL File] 1957235-99-2.mol
[Molecular Weight] 487.43

Chemical Properties	Back Directory
[form ] Solid
[color ] Light green to green

Safety Data	Back Directory
[Symbol(GHS) ] GHS06,GHS08
[Signal word ] Danger
[Hazard statements ] H301-H312-H361
[Precautionary statements ] P501-P270-P202-P201-P264-P280-P308+P313-P362+P364-P301+P310+P330-P302+P352+P312-P405

Hazard Information	Back Directory
[Uses] Thalidomide-4-O-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13 (HY-114421), a degrader of FKBP12F36V and BET[1].
[IC 50] Cereblon
[References] [1] Erb MA, et al. Transcription control by the ENL YEATS domain in acute leukaemia. Nature. 2017 Mar 9;543(7644):270-274. DOI:10.1038/nature21688

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