| Identification | Back Directory | [Name]
spisulosine | [CAS]
196497-48-0 | [Synonyms]
ES 285
spisulosine
Spisulosine 285
1-deoxysphinganine
2S-Amino-3R-octadecanol
1-deoxysphinganine (M18:0)
3-Octadecanol, 2-amino-, (2S,3R)-
1-DEOXYSPHINGANINE (M18:0);1-DEOXYSPHINGANINE | [Molecular Formula]
C18H39NO | [MOL File]
196497-48-0.mol | [Molecular Weight]
285.51 |
| Chemical Properties | Back Directory | [Melting point ]
115-116 °C | [Boiling point ]
405.3±18.0 °C(Predicted) | [density ]
0.871±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/ml; DMSO: 2 mg/ml; Ethanol: miscible | [form ]
A crystalline solid | [pka]
12.90±0.45(Predicted) | [color ]
White to off-white | [InChI]
1S/C18H39NO/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18(20)17(2)19/h17-18,20H,3-16,19H2,1-2H3/t17-,18+/m0/s1 | [InChIKey]
YRYJJIXWWQLGGV-ZWKOTPCHSA-N | [SMILES]
C[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCCC |
| Hazard Information | Back Directory | [Uses]
1-deoxysphinganine may be used for the complex preparation with bovine serum albumin for cytotoxicity testing in MN9D dopaminergic neuroblastoma cell line. It is also suitable for use as a neurotoxic agent in human CD8+ T cells. | [Definition]
ChEBI: 1-deoxysphinganine is a bioactive sphingoid, sphinganine, in which the terminal hydroxy group has been replaced by a hydrogen. It has a role as an antineoplastic agent. It is a sphingoid and an amino alcohol. It is functionally related to a sphinganine. It is a conjugate base of a 1-deoxysphinganine(1+). | [Biological Activity]
1-deoxysphinganine elicits cytotoxicity towards dorsal root ganglion (DRG) neurons by disrupting the neuronal cytoskeleton formation. High levels of 1-deoxysphinganine in diabetic patients may contribute to the reduction of pancreatic β cell functionality. In hereditary sensory and autonomic neuropathy type Imutation in the serine palmitoyltransferase gene results in altered substrate specificityresulting in the accumulation of 1-deoxysphinganine. | [IC 50]
PKCζ |
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Alfa Chemistry
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https://www.alfa-chemistry.com |
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