| Identification | Back Directory | [Name]
N3-PEG4-CHO | [CAS]
2030118-14-8 | [Synonyms]
N3-PEG4-ALD
N3-PEG4-CHO
Ald-PEG4-azide
Ald-C2-PEG4-azide
N3-PEG4-CH2CH2CHO | [Molecular Formula]
C11H21N3O5 | [MDL Number]
MFCD30527403 | [MOL File]
2030118-14-8.mol | [Molecular Weight]
275.31 |
| Hazard Information | Back Directory | [Description]
Ald-PEG4-azide is a PEG linker with an aldehyde and azide end groups. Aldehyde is reactive toward hydrazide and aminooxy groups The azide group can react with alkynes, DBCO and BCN for copper-catalyzed Click Chemistry reactions. PEG linker increases the water solubility of the compound. | [Uses]
Ald-C2-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Ald-C2-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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