| Identification | Back Directory | [Name]
N-(Amino-PEG3)-N-bis(PEG3-t-butyl ester) HCl salt | [CAS]
2055042-62-9 | [Synonyms]
DUN 42629
N-(Amino-PEG3)-N-bis(PEG3-Boc)
N-(Amino-PEG3)-N-bis(PEG3-t-butyl)
N-(Amino-PEG3)-N-bis(PEG3-t-butyl ester) HCl salt
4,7,10,16,19,22-Hexaoxa-13-azapentacosanedioic acid, 13-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]-, 1,25-bis(1,1-dimethylethyl) ester | [Molecular Formula]
C34H68N2O13 | [MDL Number]
MFCD30182037 | [MOL File]
2055042-62-9.mol | [Molecular Weight]
712.91 |
| Chemical Properties | Back Directory | [Boiling point ]
690.7±50.0 °C(Predicted) | [density ]
1.072±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [pka]
8.74±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
N-(Amino-PEG3)-N-bis(PEG3-t-butyl ester) is a 3-arm PEG linker consisting of an amino group with two t-butyl esters. The amino (NH2) groups is reactive with activated NHS esters or carboxylic acid. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
N-(Amino-PEG3)-N-bis(PEG3-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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