| Identification | More | [Name]
Benzamidine hydrochloride hydrate | [CAS]
206752-36-5 | [Synonyms]
AMIDINOBENZENE HYDROCHLORIDE HYDRATE
BENZAMIDINE HCL HYDRATE
BENZAMIDINE HYDROCHLORIDE HYDRATE
BENZAMIDINE HYDROCHLORIDE MONOHYDRATE
BENZAMIDINE HYDROCHLORIDE N-HYDRATE
BENZAMIDINIUM CHLORIDE HYDRATE
BENZENECARBOXIMIDAMIDE HYDROCHLORIDE HYDRATE
BENZAMIDINE HYDROCHLORIDE HYDRATE, 98%, WATER CA 10-14% | [EINECS(EC#)]
216-795-4 | [Molecular Formula]
C7H11ClN2O | [MDL Number]
MFCD00066285 | [Molecular Weight]
174.63 | [MOL File]
206752-36-5.mol |
| Chemical Properties | Back Directory | [Appearance]
white fine crystalline powder | [Melting point ]
86-88 °C(lit.) | [storage temp. ]
0-6°C | [solubility ]
H2O: soluble50mg/mL, clear to slightly hazy, colorless to faintly yellow | [form ]
Powder | [color ]
White to off-white | [PH]
5 (50g/l, H2O, 20℃) | [biological source]
synthetic (organic) | [Water Solubility ]
soluble | [Sensitive ]
Hygroscopic | [BRN ]
3594959 | [InChI]
InChI=1S/C7H8N2.ClH.H2O/c8-7(9)6-4-2-1-3-5-6;;/h1-5H,(H3,8,9);1H;1H2 | [InChIKey]
BQVJCMMLDJPBFZ-UHFFFAOYSA-N | [SMILES]
C(C1C=CC=CC=1)(N)=N.Cl.O | [CAS DataBase Reference]
206752-36-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P280a-P304+P340-P305+P351+P338-P405-P501a | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
CV6260000 | [F ]
3-21 | [TSCA ]
Yes | [HS Code ]
29251900 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
white fine crystalline powder | [Uses]
Benzamidine hydrochloride hydrate has been used:
- in western blot analysis
- in immunoprecipitation
- in the purification of yeast dynein
- as a protease inhibitor in the preparation of brush-border membrane vesicles
- for the processing of human synovial fluid, blood and eye sleep
- to prevent non-specific degradation of cartilages
| [Uses]
Benzamidine hydrochloride hydrate is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases. It is a proteolytic inhibitor and apoptosis reagent. | [Application]
Benzamidine hydrochloride hydrate has been used:
in western blot analysis
in immunoprecipitation
in the purification of yeast dynein
as a protease inhibitor in the preparation of brush-border membrane vesicles
for the processing of human synovial fluid, blood and eye sleep
to prevent non-specific degradation of cartilages | [Biological Activity]
Peptidase inhibitor.
Benzamidine HCl is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases.A concentration of approximately 1 mM is used for general protease inhibition. To inhibit proteases from yeast, a range of 0.5 to 4.0 mM is used and it is for the most part interchangeable with pepstatin A.
In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma. | [Biochem/physiol Actions]
Peptidase inhibitor. | [Purification Methods]
Recrystallise it from dilute HCl (crystals contain xH2O) or EtOH/few drops HCl; dry it in a vacuum. It is a proteolytic inhibitor [Jeffcoate & White J Clin Endocrinol Metab 38 155 1974, Beilstein 9 IV 898.] | [Preparation and handling]
Benzamidine HCl is soluble in water and alcohol. Solubility testing in water at a concentration of 50 mg/ml yields a clear solution with heating. Benzamidine HCl is sensitive to oxidation. It is recommended to prepare solutions fresh each time in degassed water prior to use. However, frozen aliquots stored under inert gas, to exclude air, may be stable for a short time. Insufficient information is available to assess the shelf-life of a frozen solution. | [Precautions]
Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents. It is hygroscopic in nature. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
| Company Name: |
Maya High Purity Chemicals
|
| Telephone: |
+86 (573) 82222445 (0)18006601000 452520369 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15221/0_EN.htm |
|