| Identification | Back Directory | [Name]
4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride | [CAS]
2245697-88-3 | [Synonyms]
-ether-alkylC6-amine
3-dione hydrochloride
4-((6-aminohexyl)oxy)-2-(2
Thalidomide-O-C6-NH2 hydrochloride
4-((6-Aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
4-[(6-aminohexyl)oxy]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride
1H-?Isoindole-?1,?3(2H)?-?dione, 4-?[(6-?aminohexyl)?oxy]?-?2-?(2,?6-?dioxo-?3-?piperidinyl)?-?, hydrochloride | [Molecular Formula]
C19H24ClN3O5 | [MDL Number]
MFCD31689259 | [MOL File]
2245697-88-3.mol | [Molecular Weight]
409.87 |
| Hazard Information | Back Directory | [Description]
Thalidomide-O-C6-Amine HCl is a functionalized cereblon ligand used for PROTAC research. It incorporates an E3 ligase ligand and a C6 alkyl linker to conjugate to a target protein. | [Uses]
Thalidomide-4-O-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12F36V and BET[1]. | [IC 50]
Cereblon | [storage]
Store at -20°C | [References]
[1] Erb MA, et al. Transcription control by the ENL YEATS domain in acute leukaemia. Nature. 2017 Mar 9;543(7644):270-274. DOI:10.1038/nature21688 |
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