| Identification | Back Directory | [Name]
Propargyl-PEG10-amine | [CAS]
2112737-25-2 | [Synonyms]
Propargyl-PEG10-NH2
Propargyl-PEG10-amine
3,6,9,12,15,18,21,24,27,30-Decaoxatritriacont-32-yn-1-amine | [Molecular Formula]
C23H45NO10 | [MDL Number]
MFCD30730361 | [MOL File]
2112737-25-2.mol | [Molecular Weight]
495.6 |
| Chemical Properties | Back Directory | [Boiling point ]
545.5±45.0 °C(Predicted) | [density ]
1.079±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C, sealed storage, away from moisture and light | [form ]
Liquid | [pka]
8.74±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG10-amine is a PEG reagent that is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The propargyl group enables Click Chemistry reactions with azide-bearing compounds or biomolecules; copper catalyst is required. | [Uses]
Propargyl-PEG10-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG10-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] Guangrong Zheng, et al. Bcl-2 proteins degraders for cancer treatment. WO2019144117A1. |
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